Eptotermin alfa
Opgenra, Osigraft (eptotermin alfa) is a protein pharmaceutical. Eptotermin alfa was first approved as Osigraft on 2001-05-17. It has been approved in Europe to treat spondylolisthesis and tibial fractures. It is known to target bone morphogenetic protein receptor type-2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| musculoskeletal diseases | D009140 |
| wounds and injuries | D014947 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spondylolisthesis | D013168 | EFO_0007493 | M43.1 | — | — | — | — | 3 | 3 |
| Intervertebral disc degeneration | D055959 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Eptotermin alfa |
| INN | eptotermin alfa |
| Description | Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene.
|
| Classification | Protein |
| Drug class | growth factors: bone morphogenetic proteins; growth factors: transforming growth factors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108594 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | IT063R5MY0 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
BMPR2
BMPR2
Organism
Homo sapiens
Gene name
BMPR2
Gene synonyms
PPH1
NCBI Gene ID
Protein name
bone morphogenetic protein receptor type-2
Protein synonyms
BMP type II receptor, BMP type-2 receptor, BMPR-II, Bone morphogenetic protein receptor type II, bone morphogenetic protein receptor, type II (serine/threonine kinase), type II activin receptor-like kinase, type II receptor for bone morphogenetic protein-4
Uniprot ID
Mouse ortholog
Bmpr2 (12168)
bone morphogenetic protein receptor type-2 (O35607)
Variants
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Safety
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Adverse Events
0 adverse events reported
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